Prefontal Cortical Function in People at Ultra-High Risk for Psychosis: An Frmi Study of Reflexive Eye Movements

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

S Liu, I Agartz, P Allen, GP Amminger, OA Andreassen, P Bachman, I Baeza, H Baldwin, CF Bartholomeusz, S Borgwardt, S Catalano, X Chen, KIK Cho, S Choi, T Colibazzi, RE Cooper, CM Corcoran, VL Cropley, L de Haan, C de la Fuente-Sandoval

2026-03-01

Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psyc..

The relationship between subjective sleep disturbance and attenuated psychotic symptoms after accounting for anxiety and depressive symptoms

MJC Formica, M Fuller-Tyszkiewicz, I Hickie, L Olive, SJ Wood, R Purcell, AR Yung, LJ Phillips, B Nelson, C Pantelis, PD McGorry, JA Hartmann

2023-08-01

Background and hypotheses: Sleep disturbances are increasingly recognized as cooccurring with psychotic symptoms. The potential im..

Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?

MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson

2022-05-01

Background: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclea..

Association of Structural Magnetic Resonance Imaging Measures with Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis

M Jalbrzikowski, RA Hayes, SJ Wood, D Nordholm, JH Zhou, P Fusar-Poli, PJ Uhlhaas, T Takahashi, G Sugranyes, YB Kwak, DH Mathalon, N Katagiri, CI Hooker, L Smigielski, T Colibazzi, E Via, J Tang, S Koike, PE Rasser, C Michel

2021-07-01

Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at..

Persistent negative symptoms in individuals at Ultra High Risk for psychosis

AR Yung, B Nelson, PD McGorry, SJ Wood, A Lin

2019-04-01

Persistent negative symptoms (PNS) defined as negative symptoms that persist for at least six months in the absence of high levels..

Individualized prediction of transition to psychosis in 1,676 individuals at clinical high risk: Development and validation of a multivariable prediction model based on individual patient data meta-analysis

A Malda, N Boonstra, H Barf, S De Jong, A Aleman, J Addington, M Pruessner, D Nieman, L De Haan, A Morrison, A Riecher-Rössler, E Studerus, S Ruhrmann, F Schultze-Lutter, SK An, S Koike, K Kasai, B Nelson, P McGorry, S Wood

2019-01-01

Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The nex..

Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis

A Mechelli, A Lin, S Wood, P McGorry, P Amminger, S Tognin, P McGuire, J Young, B Nelson, A Yung

2017-06-01

Recent studies have reported an association between psychopathology and subsequent clinical and functional outcomes in people at u..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

RLEP Reniers, A Lin, AR Yung, N Koutsouleris, B Nelson, VL Cropley, D Velakoulis, PD McGorry, C Pantelis, SJ Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

B Nelson, HP Yuen, A Lin, SJ Wood, PD McGorry, JA Hartmann, AR Yung

2016-07-01

Background: The rate of transition to psychotic disorder in ultra high risk (UHR) patients has declined in recent cohorts. The rea..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

VL Cropley, A Lin, B Nelson, RLEP Reniers, AR Yung, CF Bartholomeusz, P Klauser, D Velakoulis, P McGorry, SJ Wood, C Pantelis

2016-06-01

Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the ..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis

2016-06-01

Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect

JA Hartmann, HP Yuen, PD McGorry, AR Yung, A Lin, SJ Wood, S Lavoie, B Nelson

2016-01-01

During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder...

Demographic and clinical characteristics of young people seeking help at youth mental health services: Baseline findings of the Transitions Study

R Purcell, AF Jorm, IB Hickie, AR Yung, C Pantelis, GP Amminger, N Glozier, E Killackey, LJ Phillips, SJ Wood, S Harrigan, A Mackinnon, E Scott, DF Hermens, AJ Guastella, A Kenyon, L Mundy, A Nichles, A Scaffidi, D Spiliotacopoulos

2015-12-01

Aim: The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problem..

Neighbourhood characteristics and the rate of identification of young people at ultra-high risk for psychosis

B O'Donoghue, AR Yung, S Wood, A Thompson, A Lin, P McGorry, B Nelson

2015-12-01

There is a higher incidence of psychotic disorders in more socially deprived neighbourhoods and a higher risk in migrants living i..

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

VL Cropley, CF Bartholomeusz, P Wu, SJ Wood, T Proffitt, WJ Brewer, PM Desmond, D Velakoulis, C Pantelis

2015-11-30

Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. ..

The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment

RLEP Reniers, B Garner, C Phassouliotis, LJ Phillips, C Markulev, C Pantelis, S Bendall, PD McGorry, SJ Wood

2015-02-28

Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may p..

Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

BRE Ansell, DB Dwyer, SJ Wood, E Bora, WJ Brewer, TM Proffitt, D Velakoulis, PD McGorry, C Pantelis

2015-02-12

Background Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics (..

Social environmental risk factors for transition to psychosis in an Ultra-High Risk population

Brian O'Donoghue, Barnaby Nelson, Hok Pan Yuen, Abbie Lane, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Alison R Yung

2015-02-01

Social environmental risk factors for transition to psychosis in an Ultra-High Risk population

B O'Donoghue, B Nelson, HP Yuen, A Lane, S Wood, A Thompson, A Lin, P McGorry, AR Yung

2015-02-01

Objective: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk fa..

Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin, A Riecher-Rössler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli

2014-02-01

Background Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have ..

Clinical neuropsychology within adolescent and young-adult psychiatry: Conceptualizing theory and practice

K Allott, TM Proffitt, PD McGorry, C Pantelis, SJ Wood, M Cumner, WJ Brewer

2013-09-05

Historically, clinical neuropsychology has made significant contributions to the understanding of brain-behavior relationships, pa..

Neurocognitive functioning in the prodrome of mania - An exploratory study

A Ratheesh, A Lin, B Nelson, SJ Wood, W Brewer, J Betts, M Berk, P McGorry, AR Yung, A Bechdolf

2013-05-01

Background: Cognitive deficits have been well documented in individuals with bipolar disorder (BD) after the first episode of mani..

Long-term follow-up of a group at ultra high risk ("Prodromal") for psychosis the PACE 400 study

B Nelson, HP Yuen, SJ Wood, A Lin, D Spiliotacopoulos, A Bruxner, C Broussard, M Simmons, DL Foley, WJ Brewer, SM Francey, GP Amminger, A Thompson, PD McGorry, AR Yung

2013-01-01

IMPORTANCE The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disorde..

Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study

A Bechdolf, SJ Wood, B Nelson, D Velakoulis, M Yücel, T Takahashi, AR Yung, M Berk, MT Wong, C Pantelis, PD McGorry

2012-01-30

There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear wheth..

Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection

TJ Whitford, P Savadjiev, M Kubicki, LJ O'Donnell, DP Terry, S Bouix, CF Westin, JS Schneiderman, L Bobrow, AC Rausch, M Niznikiewicz, PG Nestor, C Pantelis, SJ Wood, RW McCarley, ME Shenton

2011-10-01

Background: Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and tem..

Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study

KL Hannan, SJ Wood, AR Yung, D Velakoulis, LJ Phillips, B Soulsby, G Berger, PD McGorry, C Pantelis

2010-06-30

The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psycho..

Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

T Takahashi, SJ Wood, AR Yung, M Walterfang, LJ Phillips, B Soulsby, Y Kawasaki, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2010-03-01

Background: Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the t..

Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia

L Cocchi, M Walterfang, R Testa, SJ Wood, ML Seal, J Suckling, T Takahashi, TM Proffitt, WJ Brewer, C Adamson, B Soulsby, D Velakoulis, PD McGorry, C Pantelis

2009-12-01

Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network in..

Neurobiological markers of illness onset in psychosis and schizophrenia: The search for a moving target

C Pantelis, M Yücel, E Bora, A Fornito, R Testa, WJ Brewer, D Velakoulis, SJ Wood

2009-09-03

In this review, we describe neuropsychological and brain imaging findings in the early stages of psychosis and schizophrenia. We f..

An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders

T Takahashi, SJ Wood, B Soulsby, Y Kawasaki, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2009-09-01

Morphologic abnormalities of the superior temporal gyrus (STG) have been reported in schizophrenia, but have not been extensively ..

Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis

M Walterfang, AG Wood, DC Reutens, SJ Wood, J Chen, D Velakoulis, PD McGorry, C Pantelis

2009-07-15

Reductions in the size of the anterior callosum have been described for both first-episode and established schizophrenia and bipol..

Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory

C Pantelis, SJ Wood, TM Proffitt, R Testa, K Mahony, WJ Brewer, JA Buchanan, D Velakoulis, PD McGorry

2009-07-01

Patients with established schizophrenia perform poorly on attentional set-shifting tasks, due to a failure of inhibitory control a..

Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders

T Takahashi, SJ Wood, B Soulsby, R Tanino, MTH Wong, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2009-06-15

Volume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disor..

Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis

T Takahashi, SJ Wood, AR Yung, LJ Phillips, B Soulsby, PD McGorry, R Tanino, SY Zhou, M Suzuki, D Velakoulis, C Pantelis

2009-06-01

Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains u..

Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis

T Takahashi, SJ Wood, AR Yung, B Soulsby, PD McGorry, M Suzuki, Y Kawasaki, LJ Phillips, D Velakoulis, C Pantelis

2009-04-01

Context: Longitudinal magnetic resonance imaging studies have shown progressive gray matter reduction in the superior temporal gyr..

Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia

T Takahashi, SJ Wood, B Soulsby, PD McGorry, R Tanino, M Suzuki, D Velakoulis, C Pantelis

2009-03-01

Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains u..

Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals

D Sun, L Phillips, D Velakoulis, A Yung, PD McGorry, SJ Wood, TGM van Erp, PM Thompson, AW Toga, TD Cannon, C Pantelis

2009-03-01

Background: Schizophrenia and related psychoses are associated with brain structural abnormalities. Recent findings in 'at risk' p..

Brain surface contraction mapped in first-episode schizophrenia: A longitudinal magnetic resonance imaging study

D Sun, GW Stuart, M Jenkinson, SJ Wood, PD McGorry, D Velakoulis, TGM Van Erp, PM Thompson, AW Toga, DJ Smith, TD Cannon, C Pantelis

2009-01-01

Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains uncle..

Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders

T Takahashi, M Yücel, AR Yung, SJ Wood, LJ Phillips, GE Berger, A Ang, B Soulsby, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2008-10-01

Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI) has been reported in psychotic disorders, ..

Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders

T Takahashi, AR Yung, M Yücel, SJ Wood, LJ Phillips, IH Harding, B Soulsby, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2008-10-01

An increased prevalence of large cavum septum pellucidum (CSP), a marker of midline neurodevelopmental abnormality, has been repor..

Abnormal white matter microstructure in schizophrenia: A voxelwise analysis of axial and radial diffusivity

ML Seal, M Yücel, A Fornito, SJ Wood, BJ Harrison, M Walterfang, GS Pell, C Pantelis

2008-04-01

Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated b..

Olfactory impairments in child attention-deficit/hyperactivity disorder

FR Karsz, A Vance, VA Anderson, PG Brann, SJ Wood, C Pantelis, WJ Brewer

2008-01-01

Objective: This study compared unilateral olfactory identification abilities in children with and without attention-deficit/hypera..

Fractionation of Verbal Memory Impairment in Schizophrenia and Schizophreniform Psychosis

Stephen J Wood, Aleks U Tarnawski, Tina M Proffitt, Warrick J Brewer, Greg R Savage, Vicki Anderson, Patrick D McGorry, Stephen J Wood, Aleks U Tarnawski, Tina M Proffitt, Warrick J Brewer, Greg R Savage, Vicki Anderson, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis

2007-09-01

<jats:p> Objectives: The characterization, aetiology, and course of verbal memory deficits in schizophrenia remain ill defined. Th..